In recent years, facial aesthetics has shifted away from simply filling lines or freezing movement, and towards treatments that genuinely improve skin quality. We think one of the most exciting developments in this space is polynucleotide therapy.
Polynucleotides are not about changing how you look. They are about helping your skin function better, heal better, and age more gracefully. If you are interested in polynucleotides in Cheltenham, you can find out more by booking a consultation with our award-winning principal dentist, Dr Imran Nasser.
Book a consultation now View our Facial Aesthetics Programmes here
Polynucleotides are naturally derived molecules, originally sourced from purified DNA fragments. In aesthetic medicine, they are used to stimulate skin regeneration at a cellular level.
Rather than adding volume or altering facial structure, polynucleotides work by supporting the skin’s own repair and renewal processes. Think of them as a bio-stimulatory treatment that improves the environment of the skin, allowing it to behave in a healthier, more youthful way. Additionally, they possess anti-inflammatory properties, offering a comprehensive approach to skin rejuvenation.
One of the reasons polynucleotides are generating so much interest is that they align perfectly with a modern, regenerative approach to facial aesthetics. Rather than masking the signs of ageing, they help address the underlying skin biology.
The result is skin that looks healthier, calmer, better hydrated, and more resilient, not “done”, just well cared for.
Polynucleotide treatments offer a wide range of benefits, which is why they are becoming increasingly popular for patients looking for natural, progressive results.
Deep hydration and skin glow: Polynucleotides improve water retention within the skin, helping to restore hydration from the inside out. Well-hydrated skin reflects light better, which is why patients often notice a healthy glow and improved skin luminosity after treatment.
Collagen stimulation and skin quality: They support fibroblast activity, the cells responsible for producing collagen and elastin. Over time, this leads to firmer, stronger skin with improved texture and elasticity, rather than a temporary surface effect.
Antioxidant and anti-inflammatory effects: Polynucleotides have powerful antioxidant properties. This means they help neutralise free radicals and reduce chronic inflammation in the skin, both of which are key drivers of ageing.
Because of these anti-inflammatory effects, polynucleotides are particularly helpful for:
By improving cellular communication and tissue repair, polynucleotides help the skin heal more efficiently. This makes them an excellent option for patients who feel their skin looks tired, thin, damaged, or is slow to recover.
Polynucleotides are extremely versatile and can be used in areas where traditional injectables may not be suitable, including:
They are particularly popular around the eyes due to their ability to improve skin quality without adding volume.
For optimal results, polynucleotide therapy is carried out as a course rather than a one-off treatment. With an initial course of three treatment sessions, spaced four weeks apart and then maintenance with one treatment every six months to maintain skin quality and ongoing regeneration.
Results build gradually over time, with improvements in hydration often seen early, followed by longer-term improvements in texture, firmness, and overall skin health.
Polynucleotides are suitable for a wide range of patients, including those who:
They can also be safely combined with other treatments such as botulinum toxin, skin boosters, and medical-grade skincare as part of a comprehensive skin rejuvenation plan.
If you would like to find out whether polynucleotide therapy is suitable for your skin, we would be very happy to guide you.
At Cheltenham & Cotswold Dental, facial aesthetic treatments such as polynucleotide therapy are carried out by Dr Imi Nasser, an award-winning aesthetic clinician with advanced training in facial anatomy, skin regeneration & dental surgery. A personalised consultation allows us to assess your skin, discuss your goals, and design a treatment plan tailored specifically to you.
To book a consultation or to speak to our team:
We look forward to helping you achieve healthier, more radiant skin through a safe, evidence-based, and regenerative approach.
While both are injectables used to rejuvenate the face, they have very different intentions. Dermal fillers use hyaluronic acid to add volume, plump deep lines, or reshape areas like the lips and cheeks for an immediate change. Polynucleotides, on the other hand, are more like a structural renovation for your skin cells. Instead of just taking up space, these DNA fractions act as messengers that tell your skin to repair itself, boost its own collagen, and improve elasticity. While fillers provide an instant lift, polynucleotides focus on improving the actual quality and health of the skin over time.
Yes, they are actually an excellent choice for those with sensitive or reactive skin. Because polynucleotides are highly purified and biocompatible, they don’t typically trigger the inflammatory response that some facial aesthetic treatments can. Beyond just being safe, they are deeply bio-stimulatory and anti-inflammatory, meaning they can actually help strengthen a compromised skin barrier and reduce redness. By improving the skin’s physiological environment from the inside out, they often leave the skin more resilient and less prone to sensitivity in the long run.
Yes, they can be combined with other treatments, and polynucleotides often work better when paired with other procedures because they prime the skin to heal more efficiently. They can be combined with microneedling or laser treatments to speed up recovery and enhance the glow or used alongside dermal fillers and wrinkle relaxing treatment to ensure the skin sitting on top of the filler looks smooth and healthy.
Polynucleotide treatments offer a range of benefits, including improved skin texture and tone, reduced fine lines and wrinkles, increased skin hydration, enhanced skin radiance, diminished acne scars, and improved skin elasticity.
The number of treatments required can vary depending on individual needs and desired results. Typically, a series of 3 treatments, spaced 4 weeks apart, is recommended. Results can last for several months, and in some cases, up to a year.
Finance options available
Denplan £24.00 per month (£24.60 per month with optional Supplementary Insurance) includes:
2x examinations 2x 30minute hygienist appointments 10% discount off routine treatmentNecessary intra-oral x rays Optional emergency insurance
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