Polynucleotides for Skin Rejuvenation

Supporting healthier, stronger, glowing skin from within

In recent years, facial aesthetics has shifted away from simply filling lines or freezing movement, and towards treatments that genuinely improve skin quality. One of the most exciting developments in this space is polynucleotide therapy.

Polynucleotides are not about changing how you look. They are about helping your skin function better, heal better, and age more gracefully.

What are polynucleotides?

Polynucleotides are naturally derived molecules, originally sourced from purified DNA fragments. In aesthetic medicine, they are used to stimulate skin regeneration at a cellular level.

Rather than adding volume or altering facial structure, polynucleotides work by supporting the skin’s own repair and renewal processes. Think of them as a biostimulatory treatment that improves the environment of the skin, allowing it to behave in a healthier, more youthful way.

How do polynucleotides improve the skin?

Polynucleotide treatments offer a wide range of benefits, which is why they are becoming increasingly popular for patients looking for natural, progressive results.

Deep hydration and skin glow

Polynucleotides improve water retention within the skin, helping to restore hydration from the inside out. Well-hydrated skin reflects light better, which is why patients often notice a healthy glow and improved skin luminosity after treatment.

Collagen stimulation and skin quality

They support fibroblast activity, the cells responsible for producing collagen and elastin. Over time, this leads to firmer, stronger skin with improved texture and elasticity, rather than a temporary surface effect.

Antioxidant and anti-inflammatory effects

Polynucleotides have powerful antioxidant properties. This means they help neutralise free radicals and reduce chronic inflammation in the skin, both of which are key drivers of ageing.

Because of these anti-inflammatory effects, polynucleotides are particularly helpful for:

• Acne-prone skin
• Post-inflammatory redness
• Scarring, including acne scarring
• Skin that is reactive or sensitised

Support for skin regeneration and healing

By improving cellular communication and tissue repair, polynucleotides help the skin heal more efficiently. This makes them an excellent option for patients who feel their skin looks tired, thin, damaged, or slow to recover.

What areas can be treated?

Polynucleotides are extremely versatile and can be used in areas where traditional injectables may not be suitable, including:

• Face
• Under-eye area
• Neck
• Décolletage
• Hands

They are particularly popular around the eyes due to their ability to improve skin quality without adding volume.

What does a treatment course look like?

For optimal results, polynucleotide therapy is carried out as a course rather than a one-off treatment.

• Initial course: Three treatment sessions, spaced four weeks apart
• Maintenance: One treatment every six months to maintain skin quality and ongoing regeneration

Results build gradually over time, with improvements in hydration often seen early, followed by longer-term improvements in texture, firmness, and overall skin health.

Who is polynucleotide treatment suitable for?

Polynucleotides are suitable for a wide range of patients, including those who:

• Want natural, subtle skin improvement
• Are not looking for volume or dramatic change
• Have concerns about skin quality, scarring, or inflammation
• Prefer treatments that support long-term skin health

They can also be safely combined with other treatments such as botulinum toxin, skin boosters, and medical-grade skincare as part of a comprehensive skin rejuvenation plan.

A more regenerative approach to aesthetics

One of the reasons polynucleotides are generating so much interest is that they align perfectly with a modern, regenerative approach to facial aesthetics. Rather than masking the signs of ageing, they help address the underlying skin biology.

The result is skin that looks healthier, calmer, better hydrated, and more resilient, not “done”, just well cared for.

Interested in polynucleotide treatment?

If you would like to find out whether polynucleotide therapy is suitable for your skin, we would be very happy to guide you.

At Cheltenham & Cotswold Dental, facial aesthetic treatments such as polynucleotide therapy are carried out by a Dr Imi Nasser, an award winning aesthetic clinician with advanced training in facial anatomy, skin regeneration & dental surgery. A personalised consultation allows us to assess your skin, discuss your goals, and design a treatment plan tailored specifically to you.

To book a consultation or to speak to our team:

• Call the practice directly
• Email us for further information
• Or complete our online enquiry form and we will be in touch

We look forward to helping you achieve healthier, more radiant skin through a safe, evidence-based, and regenerative approach.